AC   PRU00773;
DC   Domain;
TR   PROSITE; PS51443; PCS; 1; level=0
XX
Names: Phytochelatin synthase (PCS) domain
Function: Phytochelatins (PCs) are synthesized posttranslationally by the PC
 synthase (PCS) (EC 2.3.2.15), a gamma-glutamylcysteine (gamma-EC)
 transpeptidase. PC synthesis is proposed to have two distinct steps: (Step1)
 formation of gamma-EC concomitant with the cleavage of Gly from GSH; and
 (Step 2) transfer of the gamma-EC unit to an acceptor GSH molecule or an
 oligomeric PC peptide (PCn).
XX
case <FTGroup:1>
DE   + AltName: Full=Glutathione gamma-glutamylcysteinyltransferase;
DE            EC=2.3.2.15;
end case
XX
case <FTGroup:1>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly
CC         + glycine; Xref=Rhea:RHEA:17917, Rhea:RHEA-COMP:12438, Rhea:RHEA-
CC         COMP:12439, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925,
CC         ChEBI:CHEBI:131728; EC=2.3.2.15;
end case
CC   -!- SIMILARITY: Belongs to the phytochelatin synthase family.
XX
case <FTGroup:1>
GO   GO:0016756; F:glutathione gamma-glutamylcysteinyltransferase activity
GO   GO:0046938; P:phytochelatin biosynthetic process
GO   GO:0016746; F:acyltransferase activity
XX
KW   Transferase
KW   Acyltransferase
end case
XX
FT   From: PS51443
FT   DOMAIN          from..to
FT                   /note="Peptidase C83 #"
FT   ACT_SITE        56
FT   Group: 1; Condition: C
FT   ACT_SITE        168
FT   Group: 1; Condition: H
FT   ACT_SITE        186
FT   Group: 1; Condition: D
XX
Chop: Nter=0; Cter=0;
Size: 210-231;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q2TE74;
Scope:
 Eukaryota
 Bacteria; Cyanobacteriota
Comments: None;
XX
# Revision 1.10 2023/02/17
//