AC PRU00805; DC Domain; TR PROSITE; PS51471; FE2OG_OXY; 1; level=0 XX Names: Fe(2+) 2-oxoglutarate dioxygenase domain Fe(II) 2-oxoglutarate dioxygenase domain PKHD (prolyl/lysyl hydroxylase) domain P4Hc domain 2-oxoglutarate and Fe(II)-dependent oxygenases 2OG-Fe(II) oxygenase superfamily 2OG oxygenase families Function: Enzymes with the Fe(2+) and 2-oxoglutarate (2OG)-dependent dioxygenase domain typically catalyse the oxidation of an organic substrate using a dioxygen molecule, mostly by using ferrous iron as the active site cofactor and 2OG as a cosubstrate which is decarboxylated to succinate and CO2. XX case DE + RecName: EC=1.14.11.-; else case DE + RecName: EC=1.14.-.-; end case XX case CC -!- COFACTOR: CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033; CC Note=Binds 1 Fe(2+) ion per subunit.; end case XX case GO GO:0005506; F:iron ion binding end case case GO GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity else case GO GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen end case XX case KW Dioxygenase KW Iron KW Metal-binding KW Oxidoreductase end case XX FT From: PS51471 FT DOMAIN from..to FT /note="Fe2OG dioxygenase #" FT BINDING 20 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Group: 2; Condition: H FT BINDING 22 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Group: 2; Condition: D FT BINDING 70 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Group: 2; Condition: H FT BINDING 80 FT /ligand="2-oxoglutarate" FT /ligand_id="ChEBI:CHEBI:16810" FT Group: 2; Condition: [RK] XX Chop: Nter=0; Cter=0; Size: 80-160; Related: None; Repeats: 1; Topology: Undefined; Example: A1K320; Scope: Bacteria Eukaryota Viruses Comments: None; XX # Revision 1.12 2022/11/19 //