AC PRU00812; DC Domain; TR PROSITE; PS51479; ZF_RTR1; 1; level=0 XX Names: RTR1-type zinc Function: The eukaryotic protein family Rtr1/RPAP2 interacts with the C- terminal domain CTD of RNA polymerase II (RNAPII). It has been shown in yeast that Rtr1 is a CTD phosphatase that regulates RNAPII during the transition from serine 5 to serine 2 phosphorylation. Rtr1 proteins are poorly conserved overall, but they share a motif with three strictly conserved Cys residues and another residue conserved as His (in most fungi) or Cys (in animals and S. pombe), suggestive of a zinc finger motif (C-x(4)-C-x(n)-C-x(3)-[CH], where n ranges from 30 to 50). XX CC -!- SIMILARITY: Belongs to the RPAP2 family. XX case GO GO:0008270; F:zinc ion binding GO GO:0046872; F:metal ion binding XX KW Metal-binding KW Zinc KW Zinc-finger end case XX FT From: PS51479 case and and and FT ZN_FING from..to FT /note="RTR1-type #" else case and and and FT ZN_FING from..to FT /note="RTR1-type #; atypical" else FT ZN_FING from..to FT /note="RTR1-type #; degenerate" end case FT BINDING 24 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: [CH] FT BINDING 29 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: [CH] FT BINDING 61 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: [CH] FT BINDING 65 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: [CH] XX Chop: Nter=0; Cter=0; Size: 70-90; Related: None; Repeats: 1; Topology: Undefined; Example: F6RRD7; Scope: Eukaryota Comments: None; XX # Revision 1.4 2022/11/19 //