AC PRU00820; DC Domain; TR PROSITE; PS51487; NBD; 1; level=0 XX Names: NBD domain Function: The Rag-1 nonamer binding domain (NBD) is a DNA-binding domain involved in the somatic site-specific recombination reaction known as V(D)J recombination. XX CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- DOMAIN: The NBD (nonamer binding) DNA-binding domain mediates the CC specific binding to the nonamer RSS motif by forming a tightly CC interwoven homodimer that binds and synapses 2 nonamer elements, with CC each NBD making contact with both DNA molecules. Each RSS is composed CC of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer CC (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either CC 12 bp or 23 bp. CC -!- SIMILARITY: Belongs to the RAG1 family. XX GO GO:0005634; C:nucleus GO GO:0043565; F:sequence-specific DNA binding GO GO:0033151; P:V(D)J recombination XX KW DNA recombination KW DNA-binding KW Nucleus XX FT From: PS51487 FT DNA_BIND 1..68 FT /note="NBD" XX Chop: Nter=0; Cter=0; Size: 58-78; Related: None; Repeats: 1; Topology: Undefined; Example: Q91829; Scope: Eukaryota; Euteleostomi Comments: None; XX # Revision 1.4 2019/11/21 //