AC PRU00839; DC Domain; TR PROSITE; PS51506; CBL_PTB; 1; level=0 XX Names: Cbl-type phosphotyrosine-binding (Cbl-PTB) domain Cbl N-terminal (Cbl-N) domain Tyrosine kinase binding (TKB) domain Function: Cbl-PTB is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain. The calcium-bound EF-hand wedges between the 4H and SH2 domains, and roughly determines their relative orientation. The three domains together form an integrated phosphoprotein-recognition module. XX CC -!- DOMAIN: The N-terminus is composed of the phosphotyrosine binding (PTB) CC domain, a short linker region and the RING-type zinc finger. The PTB CC domain, which is also called TKB (tyrosine kinase binding) domain, is CC composed of three different subdomains: a four-helix bundle (4H), a CC calcium-binding EF hand and a divergent SH2 domain. XX GO GO:0005509; F:calcium ion binding GO GO:0007166; P:cell surface receptor signaling pathway XX KW Calcium KW Metal-binding XX FT From: PS51506 FT DOMAIN from..to FT /note="Cbl-PTB #" FT REGION from..131 FT /note="4H #" FT REGION 132..204 FT /note="EF-hand-like #" FT REGION 205..to FT /note="SH2-like #" case FT BINDING 185 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="#1" FT Tag: binds; Condition: [HCUEDKQNMYWSTRX] FT BINDING 187 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="#1" FT Tag: binds; Condition: [HCUEDKQNMYWSTRX] FT BINDING 189 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="#1" FT Tag: binds; Condition: [HCUEDKQNMYWSTRX] FT BINDING 191 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="#1" FT Tag: binds; Condition: [HCUEDKQNMYWSTRX] FT BINDING 196 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="#1" FT Tag: binds; Condition: [HCUEDKQNMYWSTRX] end case XX Chop: Nter=0; Cter=0; Size: 282-325; Related: None; Repeats: 1; Topology: Undefined; Example: Q557E7; Scope: Eukaryota Viruses; Murine leukemia virus Comments: None; XX # Revision 1.10 2022/11/19 //