AC PRU00840; DC Domain; TR PROSITE; PS51507; IRF_2; 1; level=0 XX Names: IRF tryptophan pentad repeat DNA-binding domain Function: The IRF tryptophan pentad repeat DNA-binding domain has an alpha/ beta architecture comprising a cluster of three alpha-helices (alpha1-alpha3) flanked on one side by a mixed four-stranded beta-sheet (beta1-beta4). It forms a helix-turn-helix motif that binds to ISRE consensus sequences found in target promoters. XX CC -!- SIMILARITY: Belongs to the IRF family. XX DR PROSITE; PS00601; IRF_1; 1; trigger=no XX GO GO:0006355; P:regulation of DNA-templated transcription GO GO:0006351; P:DNA-templated transcription GO GO:0005634; C:nucleus GO GO:0003677; F:DNA binding XX KW DNA-binding KW Nucleus KW Transcription KW Transcription regulation XX FT From: PS51507 FT DNA_BIND 1..107 FT /note="IRF tryptophan pentad repeat" XX Chop: Nter=0; Cter=0; Size: 95-128; Related: None; Repeats: 1; Topology: Undefined; Example: O14896; Scope: Eukaryota; Euteleostomi Comments: None; XX # Revision 1.6 2022/06/27 //