AC PRU00860; DC Domain; TR PROSITE; PS51528; FLAVIVIRUS_NS3PRO; 1; level=0 XX Names: Flavivirus NS3 protease (NS3pro) domain Function: The NS3pro has a classical serine protease catalytic triad (His, Asp, and Ser). The enzymatic activity of NS3pro is enhanced by interacting with the central 40 amino acid of NS2B which acts as an essential cofactor. XX case CC -!- FUNCTION: Serine protease NS3: Displays three enzymatic activities: CC serine protease, NTPase and RNA helicase. NS3 serine protease, in CC association with NS2B, performs its autocleavage and cleaves the CC polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B- CC NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and CC unwinds dsRNA in the 3' to 5' direction. CC -!- SUBCELLULAR LOCATION: Serine protease NS3: Host endoplasmic reticulum CC membrane; Peripheral membrane protein; Cytoplasmic side. Note=Remains CC non-covalently associated to serine protease subunit NS2B. end case XX case GO GO:0016787; F:hydrolase activity GO GO:0008233; F:peptidase activity GO GO:0008236; F:serine-type peptidase activity XX KW Cleavage on pair of basic residues KW Hydrolase KW Protease KW Serine protease end case XX FT From: PS51528 FT CHAIN ? FT /note="Serine protease NS3" FT DOMAIN from..to FT /note="Peptidase S7 #" FT ACT_SITE 53 FT /note="Charge relay system; for serine protease NS3 FT activity" FT Group: 1; Condition: H FT ACT_SITE 77 FT /note="Charge relay system; for serine protease NS3 FT activity" FT Group: 1; Condition: D FT ACT_SITE 137 FT /note="Charge relay system; for serine protease NS3 FT activity" FT Group: 1; Condition: S XX Chop: Nter=0; Cter=0; Size: 168-191; Related: None; Repeats: 1; Topology: Undefined; Example: P07564; Scope: Viruses; Flaviviridae Comments: None; XX # Revision 1.6 2019/11/21 //