AC   PRU00894;
DC   Domain;
c?   <Length>=211> and <Length<=317>
TR   PROSITE; PS51561; SAM_NNMT_PNMT_TEMT_1; 1; level=0
XX
Names: Nicotinamide N-methyltransferase (EC 2.1.1.1)
Function: Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that
 transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide
 to form 1-methylnicotinamide and S-adenosyl-L-homocysteine.
XX
DE   + RecName: EC=2.1.1.1;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide
CC         + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23884, ChEBI:CHEBI:16797,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.1;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. NNMT/PNMT/TEMT family.
XX
GO   GO:0008112; F:nicotinamide N-methyltransferase activity
GO   GO:0032259; P:methylation
GO   GO:0046500; P:S-adenosylmethionine metabolic process
XX
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
XX
FT   From: PS51561
FT   BINDING         63..64
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   BINDING         142..143
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   BINDING         20
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Y
FT   BINDING         25
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Y
FT   BINDING         69
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Y
FT   BINDING         85
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         90
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: N
FT   BINDING         163
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [AFLT]
XX
Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q06AV1;
Scope:
 Eukaryota; Metazoa
Comments: None;
XX
# Revision 1.14 2022/11/19
//