AC PRU00895; DC Domain; TR PROSITE; PS51562; RNA_CAP0_MT; 1; level=0 XX Names: mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) Function: mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and S-adenosyl-L-homocysteine. XX DE + RecName: EC=2.1.1.56; XX CC -!- CATALYTIC ACTIVITY: CC Reaction=a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S- CC adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA- CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, CC ChEBI:CHEBI:167617; EC=2.1.1.56; case CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. mRNA cap 0 methyltransferase family. else case CC -!- SIMILARITY: In the C-terminal section; belongs to the class I-like SAM- CC binding methyltransferase superfamily. mRNA cap 0 methyltransferase CC family. end case XX GO GO:0003723; F:RNA binding GO GO:0004482; F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity GO GO:0006370; P:7-methylguanosine mRNA capping GO GO:0032259; P:methylation GO GO:0046500; P:S-adenosylmethionine metabolic process XX KW Methyltransferase KW mRNA capping KW mRNA processing KW RNA-binding KW S-adenosyl-L-methionine KW Transferase XX FT From: PS51562 FT DOMAIN from..to FT /note="mRNA cap 0 methyltransferase #" FT BINDING 10..11 FT /ligand="mRNA" FT /ligand_id="ChEBI:CHEBI:33699" FT /ligand_part="mRNA cap" FT Condition: x-N case FT BINDING 91..92 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [DE]-x end case FT BINDING 117..119 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: x-F-x FT BINDING 14 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: K FT BINDING 35 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [ADCG] FT BINDING 57 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: D FT SITE 38 FT /note="mRNA cap binding" FT Condition: K FT SITE 44 FT /note="mRNA cap binding" FT Condition: K FT SITE 69 FT /note="mRNA cap binding" FT Condition: R FT SITE 121 FT /note="mRNA cap binding" FT Condition: H FT SITE 209 FT /note="mRNA cap binding" FT Condition: E FT SITE 278 FT /note="mRNA cap binding" FT Condition: Y XX Chop: Nter=0; Cter=0; Size: 220-365; Related: None; Repeats: 1; Topology: Undefined; Example: Q8SR66; P04298; Scope: Eukaryota Viruses Comments: None; XX # Revision 1.28 2024/01/11 //