AC   PRU00897;
DC   Domain;
c?   <Length>=242> and <Length<=362>
TR   PROSITE; PS51564; SAM_ICMT; 1; level=0
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Names: Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100)
Function: Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) is an
 enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a
 protein C-terminal S-farnesyl-L-cysteine to form a protein C-terminal S-
 farnesyl-L-cysteine methyl ester and S-adenosyl-L-homocysteine.
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DE   + RecName: EC=2.1.1.100;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-
CC         adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-
CC         cysteine methyl ester + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510,
CC         ChEBI:CHEBI:90511; EC=2.1.1.100;
CC   -!- SIMILARITY: Belongs to the class VI-like SAM-binding methyltransferase
CC       superfamily. Isoprenylcysteine carboxyl methyltransferase family.
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GO   GO:0004671; F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO   GO:0032259; P:methylation
GO   GO:0046500; P:S-adenosylmethionine metabolic process
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KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
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Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: O60725;
Scope:
 Eukaryota
Comments: None;
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# Revision 1.8 2019/11/21
//