AC PRU00902; DC Domain; TR PROSITE; PS51569; DOT1; 1; level=0 XX Names: Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43) Function: Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. XX case DE + RecName: EC=2.1.1.-; XX CC -!- CATALYTIC ACTIVITY: CC Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)- CC methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. DOT1 family. end case XX case GO GO:0032259; P:methylation GO GO:0042054; F:histone methyltransferase activity GO GO:0034968; P:histone lysine methylation GO GO:0016740; F:transferase activity GO GO:0008168; F:methyltransferase activity GO GO:0046500; P:S-adenosylmethionine metabolic process XX KW Methyltransferase KW S-adenosyl-L-methionine KW Transferase end case XX FT From: PS51569 FT DOMAIN from..to FT /note="DOT1 #" case FT BINDING 120..123 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: Y-G-E-x FT BINDING 143..152 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [FLV]-x-D-x-G-[ACS]-G-x-G-x FT BINDING 206..207 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: x-F end case FT BINDING 170 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Group: 1; Condition: [DE] XX Chop: Nter=0; Cter=0; Size: unlimited; Related: None; Repeats: 1; Topology: Undefined; Example: Q04089; Scope: Eukaryota Comments: None; XX # Revision 1.22 2023/03/27 //