AC PRU00910; DC Domain; c? =315> and TR PROSITE; PS51577; SAM_MT43_SET7; 1; level=0 XX Names: Histone-lysine N-methyltransferase Function: Histone-lysine N-methyltransferase is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. XX DE + RecName: EC=2.1.1.364; XX CC -!- CATALYTIC ACTIVITY: CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase CC superfamily. Histone-lysine methyltransferase family. SET7 subfamily. XX GO GO:0032259; P:methylation GO GO:0042054; F:histone methyltransferase activity GO GO:0034968; P:histone lysine methylation GO GO:0016740; F:transferase activity GO GO:0008168; F:methyltransferase activity GO GO:0046500; P:S-adenosylmethionine metabolic process XX KW Methyltransferase KW S-adenosyl-L-methionine KW Transferase XX FT From: PS51577 FT BINDING 247..249 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" XX Chop: Nter=0; Cter=0; Size: unlimited; Related: None; Repeats: 1; Topology: Undefined; Example: Q8WTS6; Scope: Eukaryota; Chordata Comments: None; XX # Revision 1.20 2023/03/27 //