AC PRU00924; DC Domain; TR PROSITE; PS51591; RNA_CAP01_NS5_MT; 1; level=0 XX Names: mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) Function: mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) is an enzyme that transfers a methyl group from SAM to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and SAH. mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) is an enzyme that transfers a methyl group from SAM to m(7)G(5')pppR-RNA to form m(7)G(5')pppRm-RNA and SAH. XX DE + RecName: EC=2.1.1.56; DE EC=2.1.1.57; XX CC -!- CATALYTIC ACTIVITY: CC Reaction=a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S- CC adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA- CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, CC ChEBI:CHEBI:167617; EC=2.1.1.56; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside CC in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- CC triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S- CC adenosyl-L-homocysteine; Xref=Rhea:RHEA:67020, Rhea:RHEA-COMP:17167, CC Rhea:RHEA-COMP:17168, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, CC ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167609; CC EC=2.1.1.57; CC -!- SIMILARITY: In the N-terminal section; belongs to the class I-like SAM- CC binding methyltransferase superfamily. mRNA cap 0-1 NS5-type CC methyltransferase family. XX GO GO:0003723; F:RNA binding GO GO:0004482; F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity GO GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity GO GO:0006370; P:7-methylguanosine mRNA capping GO GO:0032259; P:methylation GO GO:0046500; P:S-adenosylmethionine metabolic process XX KW Methyltransferase KW mRNA capping KW mRNA processing KW RNA-binding KW S-adenosyl-L-methionine KW Transferase XX FT From: PS51591 FT DOMAIN from..to FT /note="mRNA cap 0-1 NS5-type MT #" FT BINDING 56 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: S FT BINDING 86 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: G FT BINDING 87 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: W FT BINDING 104 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: T FT BINDING 105 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [ILK] FT BINDING 131 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: D FT BINDING 132 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: [IV] FT BINDING 147 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: I FT BINDING 220 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: Y FT SITE 13 FT /note="mRNA cap binding" FT Condition: K FT SITE 16 FT /note="mRNA cap binding; via carbonyl oxygen" FT Condition: L FT SITE 17 FT /note="mRNA cap binding" FT Condition: N FT SITE 19 FT /note="mRNA cap binding; via carbonyl oxygen" FT Condition: [CLM] FT SITE 24 FT /note="mRNA cap binding" FT Condition: F FT SITE 28 FT /note="mRNA cap binding" FT Condition: [KR] FT SITE 61 FT /note="Essential for 2'-O-methyltransferase activity" FT Condition: K FT SITE 146 FT /note="Essential for 2'-O-methyltransferase and N-7 FT methyltransferase activity" FT Condition: D FT SITE 150 FT /note="mRNA cap binding" FT Condition: S FT SITE 182 FT /note="Essential for 2'-O-methyltransferase activity" FT Condition: K FT SITE 213 FT /note="mRNA cap binding" FT Condition: R FT SITE 215 FT /note="mRNA cap binding" FT Condition: S FT SITE 218 FT /note="Essential for 2'-O-methyltransferase activity" FT Condition: E XX Chop: Nter=0; Cter=0; Size: unlimited; Related: None; Repeats: 1; Topology: Undefined; Example: P12823; P06935; P03314; Scope: Viruses; Flavivirus Comments: None; XX # Revision 1.21 2024/01/11 //