AC PRU00929; DC Domain; c? =235> and TR PROSITE; PS51597; SAM_HNMT; 1; level=0 XX Names: Histamine N-methyltransferase Function: Histamine N-methyltransferase (EC 2.1.1.8) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine to form N(tau) methylhistamine and S-adenosyl-L-homocysteine. XX DE + RecName: EC=2.1.1.8; XX CC -!- CATALYTIC ACTIVITY: CC Reaction=histamine + S-adenosyl-L-methionine = H(+) + N(tau)- CC methylhistamine + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:19301, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58432, CC ChEBI:CHEBI:58600, ChEBI:CHEBI:59789; EC=2.1.1.8; CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. HNMT family. XX GO GO:0046539; F:histamine N-methyltransferase activity GO GO:0032259; P:methylation GO GO:0046500; P:S-adenosylmethionine metabolic process XX KW Methyltransferase KW S-adenosyl-L-methionine KW Transferase XX FT From: PS51597 FT BINDING 28 FT /ligand="substrate" FT Condition: E FT BINDING 283 FT /ligand="substrate" FT Condition: N FT BINDING 60 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: G FT BINDING 89 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: E FT BINDING 94 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: Q FT BINDING 120 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: S FT BINDING 142 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT Condition: I FT BINDING 283 FT /ligand="substrate" FT Condition: N XX Chop: Nter=0; Cter=0; Size: unlimited; Related: None; Repeats: 1; Topology: Undefined; Example: Q5R7C3; Scope: Eukaryota; Euteleostomi Comments: None; XX # Revision 1.9 2022/11/19 //