AC   PRU00931;
DC   Domain;
TR   PROSITE; PS51599; SAM_PEMT_PEM2; 1; level=0
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Names: Phospholipid methyltransferases (EC 2.1.1.17 and EC=2.1.1.71) family
Function: Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) is an
 enzyme that  transfers a methyl group from S-adenosyl-L-methionine (SAM) to
 phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S-
 adenosyl-L-homocysteine.
 Phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) is an
 enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to
 phosphatidyl-N-methylethanolamine to form phosphatidyl-N-
 dimethylethanolamine and S-adenosyl-L-homocysteine. It also transfers a
 methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N-
 dimethylethanolamine to form phosphatidylcholine and S-adenosyl-L-
 homocysteine.
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DE   + RecName: EC=2.1.1.17;
DE   + RecName: EC=2.1.1.71;
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CC   -!- FUNCTION: Catalyzes three sequential methylation reactions of
CC       phosphatidylethanolamine (PE) by AdoMet, thereby producing
CC       phosphatidylcholine (PC).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-
CC         adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-
CC         dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:32735, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64572, ChEBI:CHEBI:64573; EC=2.1.1.71;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-
CC         adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32739,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64572;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-
CC         methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11164,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
CC   -!- SIMILARITY: Belongs to the class VI-like SAM-binding methyltransferase
CC       superfamily. PEMT/PEM2 methyltransferase family.
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GO   GO:0004608; F:phosphatidylethanolamine N-methyltransferase activity
GO   GO:0000773; F:phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO   GO:0080101; F:phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
GO   GO:0006656; P:phosphatidylcholine biosynthetic process
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KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Phospholipid biosynthesis
KW   Phospholipid metabolism
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Chop: Nter=0; Cter=0;
Size: 174-211;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q08388;
Scope:
 Eukaryota
Comments: None;
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# Revision 1.12 2019/11/21
//