AC   PRU00932;
DC   Domain;
TR   PROSITE; PS51600; SAM_GNMT; 1; level=0
XX
Names: Glycine and glycine/sarcosine N-methyltransferase
 EC 2.1.1.20 and EC 2.1.1.156
Function: Glycine N-methyltransferase (EC 2.1.1.20) is an enzyme that
 transfers a methyl group from S-adenosyl-L-methionine (SAM) to glycine to
 form sarcosine and S-adenosyl-L-homocysteine.
 Glycine/sarcosine N-methyltransferase (EC 2.1.1.156) is an enzyme that
 transfers a methyl group from S-adenosyl-L-methionine (SAM) to glycine to
 form sarcosine and S-adenosyl-L-homocysteine AND transfers a methyl group
 from S-adenosyl-L-methionine (SAM) to sarcosine to form N,N-dimethylglycine
 and S-adenosyl-L-homocysteine.
XX
case <FTGroup:1> and (<OC:Bacteria> or <OC:Archaea>)
DE   + RecName: EC=2.1.1.156;
else case <FTGroup:1>
DE   + RecName: EC=2.1.1.20;
end case
XX
case <FTGroup:1> and (<OC:Bacteria> or <OC:Archaea>)
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-
CC         dimethylglycine + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32463,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:58251, ChEBI:CHEBI:59789; EC=2.1.1.156;
else case <FTGroup:1>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-
CC         homocysteine + sarcosine; Xref=Rhea:RHEA:19937, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57305, ChEBI:CHEBI:57433, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789; EC=2.1.1.20;
end case
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Glycine N-methyltransferase family.
XX
case <FTGroup:1>
GO   GO:0017174; F:glycine N-methyltransferase activity
end case
case <FTGroup:1> and (<OC:Bacteria> or <OC:Archaea>)
GO   GO:0052730; F:sarcosine N-methyltransferase activity
end case
case <FTGroup:1>
GO   GO:0032259; P:methylation
GO   GO:0046500; P:S-adenosylmethionine metabolic process
end case
XX
case <FTGroup:1>
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
end case
XX
FT   From: PS51600
case <FTGroup:1>
FT   BINDING         122..123
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [DN]-W
end case
FT   BINDING         27
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Group: 1; Condition: Y
case <FTGroup:1>
FT   BINDING         36
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [WY]
FT   BINDING         39
FT                   /ligand="substrate"
FT   Condition: Y
FT   BINDING         46
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: R
FT   BINDING         70
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [AS]
FT   BINDING         91
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         143
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [FMLQ]
FT   BINDING         145
FT                   /ligand="substrate"
FT   Condition: [NS]
end case
FT   BINDING         179
FT                   /ligand="substrate"
FT   Group: 1; Condition: R
case <FTGroup:1>
FT   BINDING         223
FT                   /ligand="substrate"
end case
XX
Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P13255;
Scope:
 Eukaryota; Eutheria
 Bacteria
Comments: None;
XX
# Revision 1.13 2022/11/19
//