AC PRU00940; DC Domain; TR PROSITE; PS51608; SAM_MT_UBIE; 1; level=0 XX Names: UbiE family SAM-binding methyltransferase Function: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to 2-methoxy-6-all-trans-polyprenyl-1,4 benzoquinol to form 6-methoxy-3-methyl- 2-all-trans polyprenyl-1,4-benzoquinol and S-adenosyl-L-homocysteine. XX case not DE + RecName: EC=2.1.1.163; end case case or DE + RecName: EC=2.1.1.201; end case XX case not CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a CC menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640, CC Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, CC ChEBI:CHEBI:59789; EC=2.1.1.163; end case case or CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S- CC adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl- CC 1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, CC ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201; end case CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. MenG/UbiE family. XX DR PROSITE; PS01183; UBIE_1; 1; trigger=no DR PROSITE; PS01184; UBIE_2; 1; trigger=no XX GO GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity case or GO GO:0006744; P:ubiquinone biosynthetic process end case case not GO GO:0009234; P:menaquinone biosynthetic process end case GO GO:0032259; P:methylation GO GO:0046500; P:S-adenosylmethionine metabolic process XX case not KW Menaquinone biosynthesis end case KW Methyltransferase KW S-adenosyl-L-methionine KW Transferase case or KW Ubiquinone biosynthesis end case XX Chop: Nter=0; Cter=0; Size: unlimited; Related: None; Repeats: 1; Topology: Undefined; Example: Q54VN2; Scope: Eukaryota Comments: None; XX # Revision 1.11 2023/01/26 //