AC   PRU00944;
DC   Domain;
TR   PROSITE; PS51612; SAM_MT_2O_PK; 1; level=0
XX
Names: Poxvirus/kinetoplastid ribose 2'-O-methyltransferase (EC 2.1.1.57) family
Function: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
XX
DE   + RecName: EC=2.1.1.-;
XX
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Poxvirus/kinetoplastid 2'-O-MTase family.
XX
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
KW   mRNA capping
KW   mRNA processing
XX
FT   From: PS51612
FT   REGION          167..246
FT                   /note="Binding to NPH-I"
FT   Condition: P-[AIV]-A-S-S-L-K-W-R-C-P-F-P-D-Q-W-I-[KR]-D-F-Y-[IV]-P-[CH]-G-[DN]-[EK]-[FM]-[LS]-Q-P-F-A-P-[PS]-[FY]-S-A-E-M-R-L-L-S-[CI]-Y-[ST]-[GR]-[AET]-[NP]-[IM]-R-L-[IKT]-[CR]-[IV]-[DT]-[KQ]-[NQS]-[AD]-[ASV]-[ISV]-[EKN]-Y-E-K-K-M-[FY]-Y-L-N-[KT]-[IK]-[IV]-R-[NP]-[KR]-[IV]-[IV]-[ILV]
FT   BINDING         175..178
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="mRNA cap"
FT   Condition: R-C-P-F
FT   BINDING         203..205
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="mRNA cap"
FT   Condition: S-A-E
FT   ACT_SITE        173
FT                   /note="For methyltransferase activity"
FT   Condition: K
FT   BINDING         19
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="mRNA cap"
FT   Condition: Y
FT   BINDING         38
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Q
FT   BINDING         65
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Y
FT   BINDING         67
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
FT   BINDING         71
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
FT   BINDING         90
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         93
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: R
FT   BINDING         112
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: V
FT   BINDING         134
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         180
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="mRNA cap"
FT   Condition: D
FT   BINDING         230
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="mRNA cap"
FT   Condition: E
XX
Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P07617;
Scope:
 Viruses; Chordopoxvirinae
Comments: None;
XX
# Revision 1.11 2022/11/19
//