AC   PRU00948;
DC   Domain;
c?   <Length>=211> and <Length<=317>
TR   PROSITE; PS51616; SAM_NNMT_PNMT_TEMT_2; 1; level=0
XX
Names: Amine N-methyltransferase
Function: Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers
 a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a
 methylated amine and S-adenosyl-L-homocysteine.
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DE   + RecName: EC=2.1.1.49;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a tertiary amine + S-adenosyl-L-methionine = a methylated
CC         tertiary amine + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:53928, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:137982, ChEBI:CHEBI:137983;
CC         EC=2.1.1.49;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a secondary amine + S-adenosyl-L-methionine = a methylated
CC         secondary amine + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:53924, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:137419, ChEBI:CHEBI:137984;
CC         EC=2.1.1.49;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a primary amine + S-adenosyl-L-methionine = a methylated
CC         primary amine + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:23136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:65296, ChEBI:CHEBI:131823;
CC         EC=2.1.1.49;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. NNMT/PNMT/TEMT family.
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GO   GO:0030748; F:amine N-methyltransferase activity
GO   GO:0032259; P:methylation
GO   GO:0046500; P:S-adenosylmethionine metabolic process
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KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
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FT   From: PS51616
FT   BINDING         64..65
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   BINDING         143..144
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   BINDING         21
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Y
FT   BINDING         26
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Y
FT   BINDING         70
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Y
FT   BINDING         86
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         91
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: N
FT   BINDING         164
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [FLT]
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Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: O97972;
Scope:
 Eukaryota; Euarchontoglires
Comments: None;
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# Revision 1.10 2022/11/19
//