AC   PRU00952;
DC   Domain;
TR   PROSITE; PS51620; SAM_TRM61; 1; level=0
XX
Names: tRNA (adenine(57)-N(1)/adenine(58)-N(1) or adenine(58)-N(1))-
 methyltransferase
Function: tRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220) is an
 enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to
 adenine(58) in tRNA to form N(1)-methyladenine(58) in tRNA and S-adenosyl-L-
 homocysteine.
 tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase (EC=2.1.1.219) is
 an enzyme that transfers a methyl group from the S-adenosyl-L-methionine
 (SAM) to adenine(57)/adenine(58) in tRNA to form N(1)-methyladenine57/N(1)-
 methyladenine58 in tRNA and S-adenosyl-L- homocysteine.
XX
case <OC:Archaea>
DE   + RecName: EC=2.1.1.219;
else
DE   + RecName: EC=2.1.1.220;
end case
XX
case <OC:Archaea>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-
CC         methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-
CC         methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:41740, Rhea:RHEA-COMP:9580, Rhea:RHEA-COMP:9582,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.219;
else
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC         methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43152, Rhea:RHEA-COMP:10365, Rhea:RHEA-COMP:10366,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.220;
end case
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TRM61 family.
XX
case <OC:Archaea>
GO   GO:0043827; F:tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity
else
GO   GO:0160107; F:tRNA (adenine(58)-N1)-methyltransferase activity
end case
GO   GO:0032259; P:methylation
XX
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
XX
FT   From: PS51620
FT   BINDING         102
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: S
FT   BINDING         123
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: E
FT   BINDING         151
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         170
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
XX
Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q755M8;
Scope:
 Eukaryota
Comments: None;
XX
# Revision 1.14 2023/12/14
//