AC   PRU00955;
DC   Domain;
c?   <OC:Fungi> and <Length>=1149> and <Length<=1723>
TR   PROSITE; PS51623; SAM_MT_TRMH_1; 1; level=0
XX
Names: tRNA guanosine-2'-O-methyltransferase
Function: tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme
 that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to
 form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine.
XX
DE   + RecName: EC=2.1.1.34;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-
CC         methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:20077, Rhea:RHEA-COMP:10190, Rhea:RHEA-COMP:10192,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.34;
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family.
XX
GO   GO:0003723; F:RNA binding
GO   GO:0141100; F:tRNA (guanine(18)-2'-O)-methyltransferase activity
GO   GO:0008033; P:tRNA processing
GO   GO:0032259; P:methylation
GO   GO:0046500; P:S-adenosylmethionine metabolic process
XX
KW   Methyltransferase
KW   RNA-binding
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
KW   tRNA-binding
XX
FT   From: PS51623
FT   BINDING         1389
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
FT   BINDING         1409
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: I
XX
Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q07527;
Scope:
 Eukaryota; Saccharomyces
Comments: None;
XX
# Revision 1.10 2023/10/13
//