AC   PRU00957;
DC   Domain;
TR   PROSITE; PS51625; SAM_MT_TRMB; 1; level=0
XX
Names: tRNA (guanine-N(7)-)-methyltransferase
Function: tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) is an enzyme
 that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to
 form tRNA containing N(7)-methylguanine and S-adenosyl-L-homocysteine.
XX
DE   + RecName: EC=2.1.1.33;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-
CC         methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42708, Rhea:RHEA-COMP:10188, Rhea:RHEA-COMP:10189,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269,
CC         ChEBI:CHEBI:74480; EC=2.1.1.33;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TrmB family.
XX
GO   GO:0000049; F:tRNA binding
GO   GO:0008176; F:tRNA (guanine(46)-N7)-methyltransferase activity
GO   GO:0008033; P:tRNA processing
GO   GO:0032259; P:methylation
GO   GO:0046500; P:S-adenosylmethionine metabolic process
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KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
case <OC:Eukaryota>
KW   tRNA-binding
end case
XX
FT   From: PS51625
case <OC:Eukaryota> and <Feature:PS51625:74-75=E-[IL]>
FT   BINDING         74..75
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
end case
case <OC:Eukaryota> and <Feature:PS51625:101-102=N-[AST]>
FT   BINDING         101..102
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
end case
case <OC:Eukaryota> and <Feature:PS51625:197=T>
FT   BINDING         197..199
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
end case
case <OC:Bacteria> and <Feature:PS51625:197-200=T-[AEKNRSY]-[FY]-E>
FT   BINDING         197..200
FT                   /ligand="substrate"
end case
FT   ACT_SITE        124
FT   Condition: D
case <OC:Bacteria>
FT   BINDING         49
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [DE]
end case
case <OC:Eukaryota>
FT   BINDING         51
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
end case
case <OC:Bacteria>
FT   BINDING         74
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [DE]
FT   BINDING         101
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [DEN]
end case
case <OC:Eukaryota>
FT   BINDING         121
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [CL]
end case
case <OC:Bacteria>
FT   BINDING         124
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         128
FT                   /ligand="substrate"
FT   Condition: K
FT   BINDING         160
FT                   /ligand="substrate"
FT   Condition: D
end case
XX
Chop: Nter=0; Cter=0;
Size: unlimited;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q6NU94;
Scope:
 Bacteria
 Eukaryota
Comments: None;
XX
# Revision 1.12 2023/10/13
//