AC   PRU00995;
DC   Domain;
TR   PROSITE; PS50880; TOPRIM; 1; level=0
XX
Names: Toprim domain
Function: The Toprim domain is a catalytic domain involved in DNA strand
 breakage and rejoining.
XX
case <FTGroup:1> and <FTGroup:2>
DE   + RecName: EC=5.6.2.2;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC       Note=The magnesium ions form salt bridges with both the protein and the
CC       DNA. Can also accept other divalent metal cations, such as Mn(2+) or
CC       Ca(2+).;
else case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
XX
case <FTGroup:1>
GO   GO:0000287; F:magnesium ion binding
end case
case <FTGroup:2>
GO   GO:0003677; F:DNA binding
XX
KW   DNA-binding
end case
case <FTGroup:1>
KW   Magnesium
KW   Metal-binding
end case
XX
FT   From: PS50880
FT   DOMAIN          from..to
FT                   /note="Toprim #"
FT   BINDING         7
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="#1"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: E
FT   BINDING         65
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="#1"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: D
FT   SITE            38
FT                   /note="Interaction with DNA"
FT   Group: 2; Condition: K
FT   SITE            41
FT                   /note="Interaction with DNA"
FT   Group: 2; Condition: N
XX
Chop: Nter=0; Cter=0;
Size: 105-128;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P06786;
Scope:
 Eukaryota
 Bacteria
 Archaea
 Viruses
Comments: None;
XX
# Revision 1.24 2022/11/19
//