AC   PRU01029;
DC   Domain;
TR   PROSITE; PS51692; PESTIVIRUS_NS2_PRO; 1; level=0
XX
Names: Pestivirus nonstructural protein 2 (NS2) protease domain
Function: The C-terminal-most domain of NS2 is a cysteine autoprotease
 responsible for NS2-3 cleavage. The catalytic triad is formed by His, Glu,
 and Cys. The pestivirus NS2 protease domain contains five Cys and one His
 organized in a linear fashion, suggesting the presence of a mononuclear ZnB
 site. The pestivirus NS2 protease domain forms peptidase family C74.
XX
case <FTGroup:1>
DE   + Contains:
DE   RecName: Full=Cysteine protease NS2;
DE            EC=3.4.22.-;
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CC   -!- FUNCTION: NS2 protease seems to play a vital role in viral RNA
CC       replication control and in the pathogenicity of the virus.
CC   -!- SUBCELLULAR LOCATION: Cysteine protease NS2: Host membrane; Multi-pass
CC       membrane protein.
end case
XX
GO   GO:0016020; C:membrane
case <FTGroup:1>
GO   GO:0019082; P:viral protein processing
GO   GO:0006508; P:proteolysis
end case
GO   GO:0033644; C:host cell membrane
case <FTGroup:1>
GO   GO:0004197; F:cysteine-type endopeptidase activity
end case
XX
KW   Host membrane
case <FTGroup:1>
KW   Hydrolase
end case
KW   Membrane
case <FTGroup:1>
KW   Protease
KW   Thiol protease
end case
KW   Transmembrane
KW   Transmembrane helix
XX
FT   From: PS51692
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT   DOMAIN          from..to
FT                   /note="Peptidase C74 #"
FT   ACT_SITE        7
FT                   /note="For cysteine protease NS2 activity"
FT   Group: 1; Condition: H
FT   ACT_SITE        21
FT                   /note="For cysteine protease NS2 activity"
FT   Group: 1; Condition: E
FT   ACT_SITE        72
FT                   /note="For cysteine protease NS2 activity"
FT   Group: 1; Condition: C
case <FTGroup:1>
FT   CHAIN           ?..149
FT                   /note="Cysteine protease NS2"
FT   SITE            149..149+1
FT                   /note="Cleavage; partial; cysteine protease NS2"
end case
XX
Chop: Nter=0; Cter=0;
Size: 139-249;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P19711;
Scope:
 Viruses; Pestivirus
Comments: None;
XX
# Revision 1.9 2022/09/30
//