AC   PRU01053;
DC   Domain;
TR   PROSITE; PS51716; G_IRG; 1; level=0
XX
Names: IRG-type guanine nucleotide-binding (G) domain
Function: The p47 or immunity-related GTPases (IRG) are at least as old as the
 vertebrates. The IRG proteins are an essential resistance system in the mouse
 for immunity against pathogens that enter the cell via a vacuole. Despite its
 importance for the mouse, the IRG resistance system is absent from humans
 because it has been lost during the divergent evolution of the primates. The
 IRG proteins appear to be accompanied phylogenetically by homologous
 proteins, named 'quasi IRG' (IRGQ) proteins, that probably lack nucleotide
 binding or hydrolysis function, and that may form regulatory heterodimers
 with functional IRG proteins.
XX
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. IRG family.
XX
case <Feature:PS51716:9-16=G-x(4)-G-[KM]-S> and <Feature:PS51716:59-62=D-x(2)-G> and <Feature:PS51716:116-119=[NT]-x-x-D>
GO   GO:0005525; F:GTP binding
XX
KW   GTP-binding
KW   Hydrolase
KW   Nucleotide-binding
end case
XX
FT   From: PS51716
FT   DOMAIN          from..to
FT                   /note="IRG-type G #"
XX
Chop: Nter=0; Cter=0;
Size: 140-237;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q6AYC2;
Scope:
 Eukaryota; Eutheria
Comments: None;
XX
# Revision 1.1 2020/05/11
//