AC PRU01124; DC Domain; TR PROSITE; PS51788; CULT; 1; level=0 XX Names: CULT (for Cereblon domain of Unknown activity, binding cellular Ligands and Thalidomide) domain Function: The thalidomide-binding region of cereblon is a conserved domain, CULT, carrying several invariant cysteine and tryptophan residues. The nature of the binding pocket, an aromatic cage of three tryptophan residues, suggests a role in the recognition of cationic ligands. XX XX case GO GO:0008270; F:zinc ion binding XX KW Metal-binding KW Zinc end case XX FT From: PS51788 FT DOMAIN from..to FT /note="CULT #" FT BINDING 6 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT Group: 1; Condition: C FT BINDING 9 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT Group: 1; Condition: C FT BINDING 73 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT Group: 1; Condition: C FT BINDING 76 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT Group: 1; Condition: C XX Chop: Nter=0; Cter=0; Size: 99-120; Related: None; Repeats: 1; Topology: Undefined; Example: Q56AP7; Scope: Eukaryota; Metazoa Comments: None; XX # Revision 1.8 2022/11/19 //