AC PRU01182; DC Domain; TR PROSITE; PS50249; MPN; 1; level=0 XX Names: MPN (Mpr1, Pad1 N-terminal) domain Mov34 domain JAB domain PAD-1 domain JAMM (JAB1/MPN/Mov34 metalloenzyme) domain Function: MPN+ domain-containing proteins are classified as metalloenzymes responsible for isopeptidase activity. These proteins contain a conserved glutamate (E) and a JAMM (Jab1/MPN/Mov34 metalloenzyme) motif, typically consisting of a canonical sequence (H-x-H-x[7]-S-x[2]-D) and coordinating a zinc ion. MPN- domains are recognizable by the absence of essential Zn(2+)- coordinating residues that are required for catalytic function. In protein complexes, an MPN+ domain can associate with MPN- domains for purposes that are not well understood. XX case KW Hydrolase KW Metal-binding KW Metalloprotease KW Protease KW Zinc end case XX FT From: PS50249 FT DOMAIN from..to FT /note="MPN #" FT MOTIF 77..90 FT /note="JAMM motif #" FT Condition: H-[NST]-H-x(7)-S-x(2)-D FT BINDING 77 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT Group: 1; Condition: H FT BINDING 79 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT Group: 1; Condition: H FT BINDING 90 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT Group: 1; Condition: D XX Chop: Nter=0; Cter=0; Size: 57-178; Related: None; Repeats: 1; Topology: Undefined; Example: Q9KVC9; Scope: Bacteria Eukaryota Archaea; Euryarchaeota Viruses Comments: None; XX # Revision 1.5 2022/11/19 //