AC   PRU01192;
DC   Domain;
TR   PROSITE; PS51845; PDEASE_I_2; 1; level=0
XX
Names: 3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain
Function: 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17) (PDEases)
 contain a catalytic domain of approximately 270 amino acids at the carboxyl
 terminus.
XX
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC       Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC       preferentially bind zinc ions, while site 2 has a preference for
CC       magnesium and/or manganese ions
end case
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
XX
DR   PROSITE; PS00126; PDEASE_I_1; 1; trigger=no
XX
XX
case <FTGroup:1>
GO   GO:0046872; F:metal ion binding
XX
KW   Metal-binding
end case
case <FTTag:act_site> and <FTGroup:1>
KW   Hydrolase
end case
XX
FT   From: PS51845
FT   DOMAIN          from..to
FT                   /note="PDEase #"
FT   ACT_SITE        77
FT                   /note="Proton donor"
FT   Tag: act_site; Condition: H
FT   BINDING         81
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         117
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         118
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
FT   BINDING         118
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT   Group: 1; Condition: D
FT   BINDING         229
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
XX
Chop: Nter=0; Cter=0;
Size: 300-450;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P16586;
Scope:
 Eukaryota
Comments: None;
XX
# Revision 1.4 2022/11/19
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