AC   PRU01197;
DC   Domain;
TR   PROSITE; PS51850; KARI_N; 1; level=0
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Names: KARI N-terminal domain
Function: Ketol-acid reductoisomerase (KARI; EC 1.1.1.86), also known as
 acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion
 of acetohydroxy acids into dihydroxy valerates in the second step of the
 biosynthetic pathway for the essential branched-chain amino acids valine,
 leucine, and isoleucine. KARIs are composed of two types of domains, an N-
 terminal Rossmann fold domain and one or two C-terminal knotted domains.
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CC   -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
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GO   GO:0004455; F:ketol-acid reductoisomerase activity
GO   GO:0009097; P:isoleucine biosynthetic process
GO   GO:0009099; P:valine biosynthetic process
case <FTGroup:1>
GO   GO:0050661; F:NADP binding
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KW   NADP
end case
KW   Amino-acid biosynthesis
KW   Branched-chain amino acid biosynthesis
KW   Oxidoreductase
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FT   From: PS51850
FT   DOMAIN          from..to
FT                   /note="KARI N-terminal Rossmann #"
FT   BINDING         27..30
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Group: 1
FT   ACT_SITE        110
FT   Condition: H
FT   BINDING         50
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Group: 1; Condition: R
FT   BINDING         55
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Group: 1; Condition: S
FT   BINDING         136
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Group: 1; Condition: G
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Chop: Nter=0; Cter=0;
Size: 135-205;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: A7GMU0;
Scope:
 Bacteria
 Archaea
 Eukaryota
Comments: None;
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# Revision 1.5 2022/11/19
//