AC   PRU01198;
DC   Domain;
TR   PROSITE; PS51851; KARI_C; 1; level=0
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Names: KARI C-terminal domain
Function: Ketol-acid reductoisomerase (KARI; EC 1.1.1.86), also known as
 acetohydroxy acid isomeroreductase (AHIR or AHAIR), catalyzes the conversion
 of acetohydroxy acids into dihydroxy valerates in the second step of the
 biosynthetic pathway for the essential branched-chain amino acids valine,
 leucine, and isoleucine. KARIs are composed of two types of domains, an N-
 terminal Rossmann fold domain and one or two C-terminal knotted domains.
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CC   -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
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GO   GO:0004455; F:ketol-acid reductoisomerase activity
GO   GO:0009097; P:isoleucine biosynthetic process
GO   GO:0009099; P:valine biosynthetic process
case <FTGroup:1> or <FTGroup:2>
GO   GO:0046872; F:metal ion binding
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KW   Magnesium
KW   Metal-binding
end case
KW   Amino-acid biosynthesis
KW   Branched-chain amino acid biosynthesis
KW   Oxidoreductase
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FT   From: PS51851
FT   DOMAIN          from..to
FT                   /note="KARI C-terminal knotted #"
FT   BINDING         9
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
FT   BINDING         9
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Group: 1; Condition: D
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Group: 1; Condition: E
FT   BINDING         45
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Group: 2; Condition: E
FT   BINDING         49
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Group: 2; Condition: E
case <FTGroup:2>
FT   BINDING         70
FT                   /ligand="substrate"
FT   Condition: S
end case
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Chop: Nter=0; Cter=0;
Size: 125-155;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: A7GMU0;
Scope:
 Bacteria
 Archaea
 Eukaryota
Comments: None;
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# Revision 1.4 2022/11/19
//