AC   PRU01211;
DC   Domain;
TR   PROSITE; PS51864; ASTACIN; 1; level=0
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Names: Astacin-like domain
 Peptidase family M12A domain
Function: Astacin or M12A family zinc metalloproteases are found in bacteria
 and animals. They belong to the metzincin protease family and are synthesized
 as inactive precursors. The zinc atom in these enzymes acts as an
 electrophilic center to enhance the reactivity of a water molecule prior to
 nucleophilic attack on the carbonyl carbon of the scissile peptide bond.
XX
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit
end case
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case <FTTag:catalytic> and <FTGroup:1>
DR   PROSITE; PS00142; ZINC_PROTEASE; 1; trigger=no
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GO   GO:0004222; F:metalloendopeptidase activity
end case
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
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case <FTTag:catalytic> and <FTGroup:1>
KW   Hydrolase
KW   Protease
KW   Metalloprotease
end case
case <FTGroup:1>
KW   Zinc
KW   Metal-binding
end case
case <FTTag:disulf>
KW   Disulfide bond
end case
FT   From: PS51864
FT   DOMAIN          from..to
FT                   /note="Peptidase M12A #"
FT   ACT_SITE        95
FT   Tag: catalytic; Condition: E
FT   BINDING         94
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         98
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         104
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   DISULFID        5..8
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        43..198
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        64..86
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        66..67
FT   Tag: disulf; Condition: C-x*-C
XX
Chop: Nter=0; Cter=0;
Size: 185-215;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P07584;
Scope:
 Eukaryota
 Bacteria
Comments: None;
XX
# Revision 1.4 2022/11/19
//