AC   PRU01217;
DC   Domain;
TR   PROSITE; PS51869; APP_E1; 1; level=0
XX
Names: Amyloid precursor protein (APP) E1 domain
Function: The E1 domain is a cysteine-rich region consisting of a growth
 factor like subdomain (GFLD), which binds heparin and can stimulate neurite
 outgrowth, and a copper-binding subdomain (CuBD) that binds Cu and Zn.
XX
CC   -!- SIMILARITY: Belongs to the APP family.
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DR   PROSITE; PS00319; APP_CUBD; 1; trigger=no
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GO   GO:0008201; F:heparin binding
case <FTGroup:1>
GO   GO:0046914; F:transition metal ion binding
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KW   Metal-binding
KW   Copper
end case
case <FTTag:disulf>
KW   Disulfide bond
end case
XX
FT   From: PS51869
FT   DOMAIN          from..to
FT                   /note="E1 #"
FT   REGION          from..94
FT                   /note="GFLD subdomain #"
FT   REGION          102..to
FT                   /note="CuBD subdomain #"
FT   DISULFID        11..34
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        45..89
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        70..77
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        104..158
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        129..157
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        115..145
FT   Tag: disulf; Condition: C-x*-C
FT   BINDING         118
FT                   /ligand="Cu(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29036"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: H
FT   BINDING         122
FT                   /ligand="Cu(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29036"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: H
FT   BINDING         139
FT                   /ligand="Cu(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29036"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: Y
case <FTGroup:1>
FT   SITE            141
FT                   /note="Required for Cu(2+) reduction"
FT   Condition: M
end case
XX
Chop: Nter=0; Cter=0;
Size: 155-175;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P12023;
Scope:
 Eukaryota; Metazoa
Comments: None;
XX
# Revision 1.6 2022/11/19
//