AC   PRU01221;
DC   Domain;
TR   PROSITE; PS51873; TRIAD; 1; level=0
XX
Names: TRIAD supradomain
Function: The cysteine and histidine rich TRIAD domain architecture is highly
 conserved and found only in eukaryotes. The three fingers that define the
 TRIAD supradomain always appear in the same order RING1-IBR-RING2. All
 characterized proteins containing the TRIAD supradomain have been found to
 possess E3 ligase activity.
XX
DR   PROSITE; PS00518; ZF_RING_1; 1; trigger=no
DR   PROSITE; PS50089; ZF_RING_2; 1; trigger=no
XX
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
GO   GO:0046872; F:metal ion binding
end case
case <Feature:PS51873:178=C>
GO   GO:0000209; P:protein polyubiquitination
GO   GO:0061630; F:ubiquitin protein ligase activity
GO   GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO   GO:0031624; F:ubiquitin conjugating enzyme binding
GO   GO:0000151; C:ubiquitin ligase complex
end case
XX
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4> or <FTGroup:5> or <FTGroup:6> or <FTGroup:7>
KW   Metal-binding
KW   Zinc
end case
KW   Zinc-finger
case <Feature:PS51873:178=C>
KW   Transferase
KW   Ubl conjugation pathway
end case
XX
FT   From: PS51873
FT   ZN_FING         5..56
FT                   /note="RING-type #"
FT   ZN_FING         75..138
FT                   /note="IBR-type"
FT   ZN_FING         165..194
FT                   /note="RING-type #; atypical"
FT   REGION          from..to
FT                   /note="TRIAD supradomain"
FT   ACT_SITE        178
FT   Condition: C
FT   BINDING         5
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         8
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: C
FT   BINDING         25
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: H
FT   BINDING         28
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         31
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         51
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: C
FT   BINDING         56
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: C
FT   BINDING         95
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#3"
FT   Group: 3; Condition: C
FT   BINDING         100
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#3"
FT   Group: 3; Condition: C
FT   BINDING         117
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#3"
FT   Group: 3; Condition: C
FT   BINDING         120
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#3"
FT   Group: 3; Condition: C
FT   BINDING         125
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#4"
FT   Group: 4; Condition: C
FT   BINDING         128
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#4"
FT   Group: 4; Condition: C
FT   BINDING         133
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#4"
FT   Group: 4; Condition: H
FT   BINDING         138
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#4"
FT   Group: 4; Condition: C
FT   BINDING         165
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#5"
FT   Group: 5; Condition: C
FT   BINDING         168
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#5"
FT   Group: 5; Condition: C
FT   BINDING         183
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#5"
FT   Group: 5; Condition: C
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#5"
FT   Group: 5; Condition: C
case <Feature:PS51873:202-209=C-x*-H>
FT   BINDING         191
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 6; Condition: C
FT   BINDING         194
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 6; Condition: C
FT   BINDING         202
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 6; Condition: C
FT   BINDING         209
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 6; Condition: H
else
FT   BINDING         191
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 7; Condition: C
FT   BINDING         194
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 7; Condition: C
FT   BINDING         202
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 7; Condition: H
FT   BINDING         209
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#6"
FT   Group: 7; Condition: C
end case
XX
Chop: Nter=0; Cter=0;
Size: 190-285;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q924T7;
Scope:
 Eukaryota
 Viruses; Mimivirus
Comments: None;
XX
# Revision 1.4 2022/11/19
//