AC   PRU01222;
DC   Domain;
TR   PROSITE; PS51874; PCV_3C_PRO; 1; level=0
XX
Names: Picornavirales 3C/3C-like protease domain
Function: The 3C (for the family Picornaviridae) or 3C-like (3CL) protease
 (for other families) plays a central role in the cleavage of the viral
 precursor polyprotein. In addition to its key role in processing the
 polyprotein, 3C/3C-like protease is able to cleave a number of host proteins
 to remodel the cellular environment for virus reproduction.
XX
case <FTGroup:1> or <FTGroup:2>
DE   Contains:
DE     RecName: Full=Protease 3C;
DE              EC=3.4.22.28;
DE     AltName: Full=Picornain 3C;
DE              Short=P3C;
else case <FTGroup:3>
DE   Contains:
DE     RecName: Full=Picornain 3C-like protease;
DE              EC=3.4.22.-;
DE              Short=3C-like protease;
else case <FTGroup:4>
DE   Contains:
DE     RecName: Full=3C-like protease;
DE              EC=3.4.22.-;
DE              Short=3CL-PRO;
end case
XX
case <FTGroup:1> or <FTGroup:2>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Selective cleavage of Gln-|-Gly bond in the poliovirus
CC         polyprotein. In other picornavirus reactions Glu may be substituted
CC         for Gln, and Ser or Thr for Gly.; EC=3.4.22.28;
end case
XX
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> or <FTGroup:4>
GO   GO:0004197; F:cysteine-type endopeptidase activity
XX
KW   Hydrolase
KW   Protease
KW   Thiol protease
end case
XX
FT   From: PS51874
FT   DOMAIN          from..to
FT                   /note="Peptidase C3 #"
case <OS:Foot-and-mouth disease virus>
FT   ACT_SITE        41
FT                   /note="For protease 3C activity; Proton donor/acceptor"
FT   Group: 1; Condition: H
FT   ACT_SITE        78
FT                   /note="For protease 3C activity"
FT   Group: 1; Condition: [ED]
FT   ACT_SITE        164
FT                   /note="For protease 3C activity"
FT   Group: 1; Condition: C
else case <OC:Picornaviridae>
FT   ACT_SITE        41
FT                   /note="For protease 3C activity"
FT   Group: 2; Condition: H
FT   ACT_SITE        78
FT                   /note="For protease 3C activity"
FT   Group: 2; Condition: [ED]
FT   ACT_SITE        164
FT                   /note="For protease 3C activity"
FT   Group: 2; Condition: C
else case <OC:Picornavirales>
FT   ACT_SITE        41
FT                   /note="For picornain 3C-like protease activity"
FT   Group: 3; Condition: H
FT   ACT_SITE        78
FT                   /note="For picornain 3C-like protease activity"
FT   Group: 3; Condition: [ED]
FT   ACT_SITE        164
FT                   /note="For picornain 3C-like protease activity"
FT   Group: 3; Condition: C
else
FT   ACT_SITE        41
FT                   /note="For 3C-like protease activity"
FT   Group: 4; Condition: H
FT   ACT_SITE        78
FT                   /note="For 3C-like protease activity"
FT   Group: 4; Condition: [ED]
FT   ACT_SITE        164
FT                   /note="For 3C-like protease activity"
FT   Group: 4; Condition: C
end case
XX
Chop: Nter=0; Cter=0;
Size: 170-250;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P06209;
Scope:
 Viruses; Riboviria
Comments: None;
XX
# Revision 1.3 2019/11/22
//