AC PRU01224; DC Domain; TR PROSITE; PS51876; PV_NPRO; 1; level=0 XX Names: Pestivirus N-terminal protease (Npro) domain Peptidase C53 domain Function: The pestivirus N-terminal protease Npro is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Following the first cleavage reaction, Npro does not possess any proteolytic trans-activity but acts as a viral immediate effector to modulate the host cell's antiviral defenses. XX case DE + Contains: DE RecName: Full=N-terminal protease; DE Short=N-pro; DE EC=3.4.22.-; DE AltName: Full=Autoprotease p20; XX GO GO:0019082; P:viral protein processing GO GO:0004197; F:cysteine-type endopeptidase activity XX KW Hydrolase KW Protease KW Thiol protease end case KW Inhibition of host IRF3 by virus KW Inhibition of host RLR pathway by virus KW Inhibition of host innate immune response by virus XX FT From: PS51876 FT DOMAIN from..to FT /note="Peptidase C53 #" FT ACT_SITE 49 FT /note="For N-terminal protease activity" FT Group: 1; Condition: H FT ACT_SITE 69 FT /note="For N-terminal protease activity" FT Group: 1; Condition: C case FT SITE to..to+1 FT /note="Cleavage; by autolysis" FT Condition: C-{P} end case XX Chop: Nter=0; Cter=0; Size: 165-175; Related: None; Repeats: 1; Topology: Undefined; Example: P19711; Scope: Viruses; Pestivirus Comments: None; XX # Revision 1.2 2019/11/22 //