AC PRU01225; DC Domain; TR PROSITE; PS51877; HAV_P29_PRO; 1; level=0 XX Names: Hypovirulence-associated virus (HAV) papain-like protease p29 domain Peptidase C7 domain Function: The HAV papain-like protease p29 is a cysteine protease, which forms the peptidase family C7. A Cys and a His catalytic residue are essential for autocatalytic cleavage at a glycine dipeptide clevage site located at the C- terminus of the domain. XX case DE + Contains: DE RecName: Full=Papain-like protease p29; DE EC=3.4.22.-; XX CC -!- FUNCTION: Papain-like protease p29 is a cysteine protease of the CC peptidase family C7 that contributes to hypovirulence-associated traits CC like the reduction in conidiation and laccase activity, but not to CC virulence attenuation. Acts as suppressor of RNA-mediated gene CC silencing, also known as post-transcriptional gene silencing (PTGS), a CC mechanism of viral defense that limits the accumulation of viral RNAs. CC Enhances viral dsRNA accumulation and virus transmission. Also involved CC in the reduction in orange pigmentation of the host, an effect CC independent of the intrinsic protease activity. XX GO GO:0008234; F:cysteine-type peptidase activity XX KW Hydrolase KW Protease KW Thiol protease end case XX FT From: PS51877 FT DOMAIN from..to FT /note="Peptidase C7 #" FT ACT_SITE 142 FT /note="For papain-like protease p29 activity" FT Group: 1; Condition: C FT ACT_SITE 195 FT /note="For papain-like protease p29 activity" FT Group: 1; Condition: H FT SITE to..to+1 FT /note="Cleavage; by papain-like protease p29" FT Condition: G-x XX Chop: Nter=0; Cter=0; Size: 245-255; Related: None; Repeats: 1; Topology: Undefined; Example: P10941; Scope: Viruses; Hypovirus Comments: None; XX # Revision 1.3 2019/11/22 //