AC   PRU01233;
DC   Domain;
TR   PROSITE; PS51885; NEPRILYSIN; 1; level=0
XX
Names: Neprilysin-like (M13) protease domain
Function: The neprilysin (M13) family of endopeptidases are zinc-
 metalloenzymes, the majority of which are type II integral membrane proteins
 with their active sites facing the extracellular environment.
XX
CC   -!- SIMILARITY: Belongs to the peptidase M13 family.
XX
case <FTGroup:1> and <FTGroup:2>
DR   PROSITE; PS00142; ZINC_PROTEASE; 1; trigger=no
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GO   GO:0004222; F:metalloendopeptidase activity
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KW   Hydrolase
KW   Metalloprotease
KW   Protease
end case
case <FTGroup:2>
KW   Metal-binding
KW   Zinc
end case
case <FTTag:disulf>
KW   Disulfide bond
end case
XX
FT   From: PS51885
FT   DOMAIN          from..to
FT                   /note="Peptidase M13 #"
FT   ACT_SITE        510
FT   Group: 1; Condition: E
FT   ACT_SITE        575
FT                   /note="Proton donor"
FT   Group: 1; Condition: D
FT   BINDING         509
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 2; Condition: H
FT   BINDING         513
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 2; Condition: H
FT   BINDING         571
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 2; Condition: E
FT   DISULFID        2..7
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        25..659
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        33..619
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        89..338
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        175..183
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        546..671
FT   Tag: disulf; Condition: C-x*-C
XX
Chop: Nter=0; Cter=0;
Size: 600-800;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0C2B4;
Scope:
 Eukaryota; Metazoa
 Bacteria; Lactobacillales
 Viruses; Mimivirus
Comments: None;
XX
# Revision 1.4 2022/11/19
//