AC   PRU01235;
DC   Domain;
TR   PROSITE; PS51887; APHTHOVIRUS_LPRO; 1; level=0
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Names: Aphthovirus leader protease (L(pro)) domain
 Peptidase C28 domain
Function: Aphthovirus L(pro) is a papain-like proteinase that self-cleaves
 from the nascent viral polyprotein precursor during infection and plays an
 important role in viral pathogenesis. L(pro) is known to contribute to virus
 propagation by suppressing host antiviral activity. L(pro) has an
 antagonistic effect on host antiviral responses via at least three
 mechanisms.
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case <FTGroup:1>
GO   GO:0039579; P:suppression by virus of host ISG15-protein conjugation
GO   GO:0019049; P:virus-mediated perturbation of host defense response
GO   GO:0039503; P:suppression by virus of host innate immune response
GO   GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway
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KW   Hydrolase
KW   Protease
KW   Thiol protease
KW   Modulation of host ubiquitin pathway by virus
KW   Modulation of host ubiquitin pathway by viral deubiquitinase
KW   Inhibition of host ISG15 by virus
KW   Viral immunoevasion
KW   Inhibition of host innate immune response by virus
KW   Inhibition of host interferon signaling pathway by virus
end case
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FT   From: PS51887
FT   DOMAIN          from..to
FT                   /note="Peptidase C28 #"
FT   ACT_SITE        23
FT                   /note="For leader protease activity"
FT   Group: 1; Condition: C
FT   ACT_SITE        120
FT                   /note="For leader protease activity"
FT   Group: 1; Condition: H
FT   ACT_SITE        135
FT                   /note="For leader protease activity"
FT   Group: 1; Condition: D
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Chop: Nter=0; Cter=0;
Size: 150-160;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P03311;
Scope:
 Viruses; Aphthovirus
Comments: None;
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# Revision 1.10 2023/12/14
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