AC   PRU01237;
DC   Domain;
TR   PROSITE; PS51889; RUBV_NS_PRO; 1; level=0
XX
Names: Rubella virus (RUBV) nonstructural (NS) protease domain
Function: This RUBV NS protease domain is a papain-like protease with catalytic
 dyad of Cys and His.
XX
case <FTGroup:2>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Zn(2+) is necessary for the protease activity. The protease can
CC       also function efficiently with Cd(2+) and Co(2+)
end case
CC   -!- PTM: Non-structural polyprotein p200: Specific enzymatic cleavage by
CC       its own cysteine protease yield mature proteins p150 and p90.
XX
case <FTGroup:2>
GO   GO:0046872; F:metal ion binding
end case
case <FTGroup:1>
GO   GO:0004197; F:cysteine-type endopeptidase activity
XX
KW   Hydrolase
KW   Protease
KW   Thiol protease
end case
case <FTGroup:2>
KW   Metal-binding
KW   Zinc
end case
XX
FT   From: PS51889
FT   DOMAIN          from..to
FT                   /note="Peptidase C27 #"
FT   REGION          153..184
FT                   /note="Interaction with host CALM1"
FT   REGION          194..229
FT                   /note="EF-hand-like"
FT   ACT_SITE        153
FT                   /note="For cysteine protease activity"
FT   Group: 1; Condition: C
FT   ACT_SITE        274
FT                   /note="For cysteine protease activity"
FT   Group: 1; Condition: H
FT   BINDING         176
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 2; Condition: C
FT   BINDING         179
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 2; Condition: C
FT   BINDING         228
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 2; Condition: C
FT   BINDING         274
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 2; Condition: H
case <FTGroup:1>
FT   SITE            to..to+1
FT                   /note="Cleavage; autocatalytic"
FT   Condition: G-G
end case
XX
Chop: Nter=0; Cter=0;
Size: 295-310;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q86500;
Scope:
 Viruses; Rubivirus
Comments: None;
XX
# Revision 1.4 2022/11/19
//