AC   PRU01242;
DC   Domain;
TR   PROSITE; PS51894; CV_3CL_PRO; 1; level=0
XX
Names: Caliciviridae (CV) 3C-like protease (3CLpro) domain
Function: The generation of mature Caliciviridae proteins requires that
 proteolytic clevages be effected at specific sites of the large polyprotein
 translated from the viral genomic RNA. This polyprotein processing is carried
 out by a 3C-like cysteine protease (3CLpro). The CV 3CLpro domain is
 predicted to contain a catalytic triad constituted of His, Asp and Cys
 residues, where the Cys likely represents the nucleophilic residue and Asp
 the acidic residue.
XX
DE   + RecName: EC=3.4.22.66;
case <FTGroup:1>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endopeptidase with a preference for cleavage when the P1
CC         position is occupied by Glu-|-Xaa and the P1' position is occupied by
CC         Gly-|-Yaa.; EC=3.4.22.66;
XX
GO   GO:0004197; F:cysteine-type endopeptidase activity
XX
KW   Hydrolase
KW   Protease
KW   Thiol protease
end case
XX
FT   From: PS51894
FT   DOMAIN          from..to
FT                   /note="Peptidase C24"
FT   ACT_SITE        32
FT                   /note="For 3CLpro activity"
FT   Group: 1; Condition: H
FT   ACT_SITE        53
FT                   /note="For 3CLpro activity"
FT   Group: 1; Condition: [DE]
FT   ACT_SITE        116
FT                   /note="For 3CLpro activity"
FT   Group: 1; Condition: C
XX
Chop: Nter=0; Cter=0;
Size: 130-160;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q9QEJ5;
Scope:
 Viruses; Caliciviridae
Comments: None;
XX
# Revision 1.2 2019/11/22
//