AC   PRU01254;
DC   Domain;
TR   PROSITE; PS51906; ZF_UBZ2; 1; level=0
XX
Names: Zinc finger UBZ2-type
Function: The ubiquitin-binding zinc finger (UBZ) is a type of zinc-
 coordinating beta-beta-alpha fold domain found mainly in proteins involved in
 DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion
 with cysteine or histidine residues; depending on their amino acid sequence,
 UBZ domains are classified into several families. Type 2 UBZs are CCHC-type
 zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA)
 core complex.
XX
CC   -!- DOMAIN: The UBZ2-type zinc finger binds both 'Lys-48'-and 'Lys-63'-
CC       linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.
XX
GO   GO:0043130; F:ubiquitin binding
GO   GO:0043240; C:Fanconi anaemia nuclear complex
case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
GO   GO:0046872; F:metal ion binding
XX
KW   Metal-binding
KW   Zinc
end case
KW   Zinc-finger
XX
FT   From: PS51906
case <Feature:PS51906:4=C> and <Feature:PS51906:7=C> and <Feature:PS51906:23=H> and <Feature:PS51906:27=C>
FT   ZN_FING         from..to
FT                   /note="UBZ2-type #"
else case <Feature:PS51906:4=[CH]> and <Feature:PS51906:7=[CH]> and <Feature:PS51906:23=[CH]> and <Feature:PS51906:27=[CH]>
FT   ZN_FING         from..to
FT                   /note="UBZ2-type #; atypical"
else
FT   ZN_FING         from..to
FT                   /note="UBZ2-type #; degenerate"
end case
FT   BINDING         4
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         7
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         27
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
XX
Chop: Nter=0; Cter=0;
Size: 35-40;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q6NZ36;
Scope:
 Eukaryota; Eutheria
Comments: None;
XX
# Revision 1.5 2022/11/19
//