AC   PRU01258;
DC   Domain;
TR   PROSITE; PS51910; GH18_2; 1; level=0
XX
Names: Glycosyl hydrolases family 18 (GH18) domain
Function: The GH18 family contains hydrolytic enzymes with chitinase or endo-
 N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like
 lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic
 enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric
 (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases
 (EC 3.2.1.96) hydrolyze the beta-1,4 linkage in the chitobiose core of N-
 linked glycans from glycoproteins leaving one GlcNAc residue on the
 substrate. CLPs do not display chitinase activity but some of them have been
 reported to have specific functions and carbohydrate binding property.
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CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family.
case <FTTag:ACT_SITE>
XX
DR   PROSITE; PS01095; GH18_1; 1; trigger=no
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KW   Hydrolase
KW   Glycosidase
end case
case <FTTag:disulf>
KW   Disulfide bond
end case
XX
FT   From: PS51910
FT   DOMAIN          from..to
FT                   /note="GH18 #"
FT   ACT_SITE        120
FT                   /note="Proton donor"
FT   Tag: ACT_SITE; Condition: E
case <FTGroup:1>
FT   BINDING         51..52
FT                   /ligand="chitin"
FT                   /ligand_id="ChEBI:CHEBI:17029"
FT   BINDING         78..81
FT                   /ligand="chitin"
FT                   /ligand_id="ChEBI:CHEBI:17029"
FT   BINDING         183..186
FT                   /ligand="chitin"
FT                   /ligand_id="ChEBI:CHEBI:17029"
end case
FT   BINDING         121
FT                   /ligand="chitin"
FT                   /ligand_id="ChEBI:CHEBI:17029"
FT   Group: 1; Condition: Y
FT   BINDING         302
FT                   /ligand="chitin"
FT                   /ligand_id="ChEBI:CHEBI:17029"
FT   Group: 1; Condition: W
FT   DISULFID        5..27
FT   Tag: disulf; Condition: C-x*-C
XX
Chop: Nter=0; Cter=0;
Size: 250-490;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q9BWS9;
Scope:
 Eukaryota
 Bacteria
 Viruses; Alphabaculovirus
Comments: None;
XX
# Revision 1.5 2022/11/19
//