AC   PRU01267;
DC   Domain;
TR   PROSITE; PS51919; X4E; 1; level=0
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Names: Sarbecovirus X4e domain
Function: The Sarbecovirus accessory protein X4, also called 7a or U122, is
 likely to be a type I membrane protein, with the amino-terminal hydrophilic
 domain oriented inside the lumen of the ER/Golgi or on the surface of the
 cell membrane or virus particle, depending on the localization of the
 protein. It has been suggested that X4e contains a binding site for the
 alpha(L) integrin subunit I-domain of LFA-1.
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CC   -!- FUNCTION: Non-structural protein which is dispensable for virus
CC       replication in cell culture.
CC   -!- SUBCELLULAR LOCATION: Virion. Host endoplasmic reticulum membrane;
CC       Single-pass membrane protein. Host endoplasmic reticulum-Golgi
CC       intermediate compartment membrane; Single-pass type I membrane
CC       protein. Host Golgi apparatus membrane; Single-pass membrane
CC       protein.
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum
CC       localization for type I membrane proteins.
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GO   GO:0016020; C:membrane
GO   GO:0044173; C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO   GO:0044167; C:host cell endoplasmic reticulum membrane
GO   GO:0039646; P:perturbation by virus of host G0/G1 transition checkpoint
GO   GO:0044178; C:host cell Golgi membrane
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case <FTTag:disulf>
KW   Disulfide bond
end case
KW   G0/G1 host cell cycle checkpoint dysregulation by virus
KW   Host Golgi apparatus
KW   Host endoplasmic reticulum
KW   Host membrane
KW   Host-virus interaction
KW   Membrane
KW   Modulation of host cell cycle by virus
KW   Signal
KW   Transmembrane
KW   Transmembrane helix
KW   Virion
FT   From: PS51919
FT   DOMAIN          from..to
FT                   /note="X4e #"
FT   DISULFID        8..43
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        20..52
FT   Tag: disulf; Condition: C-x*-C
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Chop: Nter=0; Cter=0;
Size: 60-75;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P59635;
Scope:
 Viruses; Sarbecovirus
Comments: None;
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# Revision 1.4 2023/07/27
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