AC PRU01270; DC Domain; TR PROSITE; PS51922; BCOV_S1_NTD; 1; level=0 XX Names: Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain BetaCoV S1-NTD Function: The receptor binding domain (RBD) of betaCoV that directly engages the receptor is commonly located in the C-terminal half of S1 [C-terminal domain (CTD)] such as in SARS-CoV, SARS-CoV-2, MERS-CoV,and BatCoV HKU4, though in rare cases such as with mouse hepatitis virus (MHV), the RBD region was identified in the S1 N-terminal domain (NTD). XX CC -!- SIMILARITY: Belongs to the betacoronaviruses spike protein family. XX GO GO:0016020; C:membrane GO GO:0019064; P:fusion of virus membrane with host plasma membrane GO GO:0044173; C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane GO GO:0075509; P:endocytosis involved in viral entry into host cell GO GO:0055036; C:virion membrane GO GO:0046813; P:receptor-mediated virion attachment to host cell GO GO:0019031; C:viral envelope GO GO:0039654; P:fusion of virus membrane with host endosome membrane GO GO:0020002; C:host cell plasma membrane XX case KW Disulfide bond end case KW Fusion of virus membrane with host endosomal membrane KW Fusion of virus membrane with host membrane KW Host cell membrane KW Host membrane KW Host-virus interaction KW Membrane KW Transmembrane KW Transmembrane helix KW Viral attachment to host cell KW Viral envelope protein KW Viral penetration into host cytoplasm KW Virion KW Virulence KW Virus entry into host cell FT From: PS51922 FT DOMAIN from..to FT /note="BetaCoV S1-NTD #" FT DISULFID 7..146 FT Tag: disulf; Condition: C-x*-C FT DISULFID 141..175 FT Tag: disulf; Condition: C-x*-C FT DISULFID 153..238 FT Tag: disulf; Condition: C-x*-C FT DISULFID 277..287 FT Tag: disulf; Condition: C-x*-C XX Chop: Nter=0; Cter=0; Size: 275-345; Related: None; Repeats: 1; Topology: Undefined; Example: P25194; Scope: Viruses; Betacoronavirus Comments: None; XX # Revision 1.3 2022/09/30 //