AC   PRU01271;
DC   Domain;
TR   PROSITE; PS51923; COV_S2_HR1; 1; level=0
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Names: Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region
Function: The S2 subunit contains two 4-3 heptad repeats (HRs) of hydrophobic
 residues, HR1 and HR2, typical of coiled coils, separated by an ~170-aa-long
 intervening domain. The S2 subunit is expected to present rearrangement of
 its HRs to form a stable 6-helix bundle fusion core.
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GO   GO:0016020; C:membrane
GO   GO:0044173; C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO   GO:0055036; C:virion membrane
GO   GO:0019031; C:viral envelope
GO   GO:0039654; P:fusion of virus membrane with host endosome membrane
GO   GO:0019064; P:fusion of virus membrane with host plasma membrane
GO   GO:0075509; P:endocytosis involved in viral entry into host cell
GO   GO:0046813; P:receptor-mediated virion attachment to host cell
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KW   Coiled coil
KW   Host membrane
KW   Host-virus interaction
KW   Membrane
KW   Viral attachment to host cell
KW   Viral envelope protein
KW   Virion
KW   Virulence
KW   Virus entry into host cell
FT   From: PS51923
FT   REGION          from..to
FT                   /note="Heptad repeat 1 (HR1) #"
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Chop: Nter=0; Cter=0;
Size: 100-125;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P12650;
Scope:
 Viruses; Orthocoronavirinae
Comments: None;
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# Revision 1.4 2022/09/30
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