AC PRU01274; DC Domain; TR PROSITE; PS51926; COV_E; 1; level=0 XX Names: Coronavirus envelope (CoV E) protein Function: Coronavirus envelope (CoV E) proteins are involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. They are ~100-residue-long polypeptides that are minor components in virions but are abundantly expressed inside infected cells. They are localized mainly to the endoplasmic reticulum (ER) and Golgi- complex where they participate in the assembly, budding, and intracellular trafficking of infectious virions. XX CC -!- FUNCTION: Plays a central role in virus morphogenesis and CC assembly. Acts as a viroporin and self-assembles in host membranes CC forming pentameric protein-lipid pores that allow ion transport. CC Also plays a role in the induction of apoptosis. CC -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the CC budding compartment of the host cell, which is located between CC endoplasmic reticulum and the Golgi complex. Interacts with CC Nucleoprotein. XX GO GO:0016020; C:membrane GO GO:0044178; C:host cell Golgi membrane GO GO:0039707; P:virus-mediated pore formation in host cell membrane XX KW Host Golgi apparatus KW Host membrane KW Membrane KW Transmembrane KW Transmembrane helix XX Chop: Nter=0; Cter=0; Size: 70-120; Related: None; Repeats: 1; Topology: Undefined; Example: P09048; Scope: Viruses; Orthocoronavirinae Comments: None; XX # Revision 1.3 2023/10/13 //