AC   PRU01293;
DC   Domain;
TR   PROSITE; PS51948; COV_NSP12_RDRP; 1; level=0
XX
Names: Coronavirus Nsp12 RNA-dependent RNA polymerase (RdRp) domain
Function: The Nsp12 RNA-dependent RNA polymerase, that includes an RdRp
 catalytic domain conserved in all RNA viruses, possesses some minimal
 activity on its own, but the addition of the Nsp7 and Nsp8 cofactors greatly
 stimulates polymerase activity.
XX
case <FTGroup:1>
DE   + AltName: Full=RNA-directed RNA polymerase;
DE            EC=2.7.7.48;
XX
CC   -!- CATALYTIC ACTIVITY: [RNA-directed RNA polymerase]:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
end case
CC   -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
XX
GO   GO:0000166; F:nucleotide binding
GO   GO:0003723; F:RNA binding
GO   GO:0039694; P:viral RNA genome replication
case <FTGroup:1>
GO   GO:0016740; F:transferase activity
GO   GO:0016779; F:nucleotidyltransferase activity
GO   GO:0003968; F:RNA-dependent RNA polymerase activity
XX
KW   Nucleotidyltransferase
KW   RNA-directed RNA polymerase
KW   Transferase
end case
KW   RNA-binding
KW   Viral RNA replication
KW   Nucleotide-binding
case <FTGroup:2>
KW   Zinc
KW   Metal-binding
end case
XX
FT   From: PS51948
FT   DOMAIN          from..to
FT                   /note="Nsp12 RNA-dependent RNA polymerase #"
FT   REGION          3..217
FT                   /note="RdRp Fingers N-ter #"
FT   REGION          218..256
FT                   /note="RdRp Palm N-ter #"
FT   REGION          257..315
FT                   /note="RdRp Fingers C-ter #"
FT   REGION          316..451
FT                   /note="RdRp Palm C-ter #"
FT   REGION          452..568
FT                   /note="RdRp Thumb #"
FT   ACT_SITE        395
FT   Group: 1; Condition: S
FT   ACT_SITE        396
FT   Group: 1; Condition: D
FT   ACT_SITE        397
FT   Group: 1; Condition: D
FT   BINDING         123
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 2; Condition: [CH]
FT   BINDING         278
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 2; Condition: [HC]
FT   BINDING         281
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 2; Condition: [CH]
FT   BINDING         282
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 2; Condition: [CH]
XX
Chop: Nter=0; Cter=0;
Size: 560-570;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0C6Y1;
Scope:
 Viruses; Orthocoronavirinae
Comments: None;
XX
# Revision 1.5 2022/11/19
//