AC   PRU01297;
DC   Domain;
TR   PROSITE; PS51952; COV_EXON_MTASE_COACT; 1; level=0
XX
Names: Coronavirus (CoV) ExoN/MTase coactivator domain
Function: Nsp10, a critical cofactor for activation of multiple replicative
 enzyme, is a small protein of ca. 140 amino acid residues that exists
 exclusively in viruses and not in prokaryotes or eukaryotes. Nsp10 is known
 to interact with both Nsp14 and Nsp16, acting as a scaffolding protein and
 stimulating their respective 3'-5' exoribonuclease (ExoN) and
 2'-O-methyltransferase (2'-O-MTase) activities.
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CC   -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
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case <FTGroup:1> or <FTGroup:2>
GO   GO:0008270; F:zinc ion binding
GO   GO:0046872; F:metal ion binding
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KW   Zinc
KW   Metal-binding
KW   Zinc-finger
end case
XX
FT   From: PS51952
FT   DOMAIN          from..to
FT                   /note="ExoN/MTase coactivator #"
FT   BINDING         74
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         77
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         83
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: H
FT   BINDING         90
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         116
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: C
FT   BINDING         119
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: C
FT   BINDING         127
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: C
FT   BINDING         129
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: C
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Chop: Nter=0; Cter=0;
Size: 135-145;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0C6Y1;
Scope:
 Viruses; Orthocoronavirinae
Comments: None;
XX
# Revision 1.5 2022/11/19
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