AC   PRU01308;
DC   Domain;
TR   PROSITE; PS51963; BCOV_NSP1_C; 1; level=0
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Names: Betacoronavirus (BetaCoV) Nsp1 C-terminal domain
Function: The Sarbecovirus Nsp1 C-terminal domain binds to the mRNA channel of
 the 40S ribosome, where it interferes with mRNA binding and inhibits host
 protein translation. This inhibition mechanism may be unique to
 Sarbecoviruses, because the C-terminal region of Nsp1 is shorter in AlphaCoVs
 and is not highly conserved amongst other BetaCoVs, including MERS-CoV.
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CC   -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
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GO   GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway
GO   GO:0039595; P:induction by virus of catabolism of host mRNA
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KW   Inhibition of host innate immune response by virus
KW   Inhibition of host interferon signaling pathway by virus
KW   Viral immunoevasion
KW   Eukaryotic host translation shutoff by virus
KW   Host mRNA suppression by virus
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FT   From: PS51963
FT   DOMAIN          from..to
FT                   /note="BetaCoV Nsp1 C-terminal #"
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Chop: Nter=0; Cter=0;
Size: 25-40;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0C6X7;
Scope:
 Viruses; Betacoronavirus
Comments: None;
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# Revision 1.1 2021/03/03
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