AC   PRU01319;
DC   Domain;
TR   PROSITE; PS51975; RNASE_H_2; 1; level=0
XX
Names: RNase H type-2 domain
Function: Ribonuclease H (RNase H) (EC 3.1.26.4) recognizes and cleaves the
 RNA strand of RNA-DNA heteroduplexes.
XX
case <FTGroup:1>
DE   + RecName: EC=3.1.26.4;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in
CC       the absence of substrate. May bind a second metal ion after substrate
CC       binding.
end case
XX
GO   GO:0003723; F:RNA binding
case <FTGroup:1>
GO   GO:0004523; F:RNA-DNA hybrid ribonuclease activity
GO   GO:0006401; P:RNA catabolic process
XX
KW   Endonuclease
KW   Hydrolase
KW   Metal-binding
KW   Nuclease
end case
XX
FT   From: PS51975
FT   DOMAIN          from..to
FT                   /note="RNase H type-2"
FT   BINDING         7
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT   Group: 1; Condition: D
FT   BINDING         8
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT   Group: 1; Condition: E
FT   BINDING         105
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT   Group: 1; Condition: D
XX
Chop: Nter=0; Cter=0;
Size: 170-235;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: B8DHN2;
Scope:
 Bacteria
 Archaea
 Eukaryota
Comments: None;
XX
# Revision 1.4 2022/11/19
//